Government Inter Science Arts and Commerce College, Lyari Moosa Lane, Karachi, also known as Government Girls Inter Science & Arts College, Moosa Lane Lyari, is a public intermediate college for girls located in Lyari, Karachi.

It offers Intermediate (FA/FSc) programs in various disciplines like Science, Arts, and Commerce. Affiliated with the Board of Intermediate Education Karachi (BIEK).

The college offers basic facilities like classrooms, labs, and a library. It can be considered as a good option for girls in Lyari seeking an intermediate education in Science, Arts, or Commerce.

The college is generally considered a well-reputed college with experienced faculty and a disciplined learning environment.