DJ Sindh Government Science College, also known as Dayaram Jethamal Sindh Government Science College, is a well-established educational institution in Karachi, Pakistan.

Founded in 1887, DJ Sindh Government Science College boasts a rich history of over 130 years. Initially an Arts college with only 28 students, it has evolved into a full-fledged institution offering programs in Arts, Sciences, Engineering, and Law.

The college offers a limited number of merit-based scholarships to high-achieving students admitted to undergraduate programs. The criteria and application process for these scholarships are usually announced around the time of admissions.

It played a crucial role in educating the people of Sindh for the first 60 years, being the only such institution in the area. DJ Sindh Government Science College is affiliated with the University of Karachi and the Board of Intermediate Education Karachi.

It offers Intermediate (Pre-Engineering and Pre-Medical) programs and Bachelor's degree programs. DJ Sindh Government Science College enjoys a strong reputation for quality education and rigorous academic standards.